Protection against LPS - induced acute lung injury by a mechanism based inhibitor 1 of NADPH - oxidase ( Type 2 ) 2

نویسندگان

  • Intae Lee
  • Chandra Dodia
  • Shampa Chatterjee
  • Sheldon I. Feinstein
  • Aron B. Fisher
چکیده

1 Protection against LPS-induced acute lung injury by a mechanism based inhibitor 1 of NADPH-oxidase (Type 2) 2 Intae Lee, Chandra Dodia, Shampa Chatterjee, Sheldon I. Feinstein, and Aron B. Fisher, 3 4 Institute for Environmental Medicine, Perelman School of Medicine, University of 5 Pennsylvania, Philadelphia, PA 6 7 8 Running head; LPS-induced lung injury 9 10 Address for correspondence and reprints: 11 Aron B. Fisher, M.D. 12 Institute for Environmental Medicine 13 University of Pennsylvania 14 3620 Hamilton Walk, 1 John Morgan Building 15 Philadelphia, PA 19104 16 Phone: 215-898-9100 17 Fax: 215-898-0868 18 [email protected] 19 20 21 22 23 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (January 31, 2014). doi:10.1152/ajplung.00374.2013

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2).

The phospholipase A2 activity of peroxiredoxin 6 is inhibited by the transition state analog, 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol (MJ33). This activity is required for the activation of NADPH oxidase, type 2. The present study evaluated the effect of MJ33 on manifestations of acute lung injury. Mice were injected intratracheally (IT) with LPS from Escherichia coli 0111:B...

متن کامل

p-Coumaric acid protects cardiac function against lipopolysaccharide-induced acute lung injury by attenuation of oxidative stress

Objective(s): Acute lung injury (ALI) has a high mortality rate and is characterized by damage to pulmonary system giving rise to symptoms such as histological alteration, lung tissue edema and production of proinflammatory cytokine. p-Coumaric acid (p-CA), as a phenolic compound, that is found in many types of fruits and vegetables has been reported to exhibit a thera...

متن کامل

NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity.

Although reactive oxygen species (ROS) produced by NADPH oxidase are known to regulate inflammatory responses, the impact of ROS on intracellular signaling pathways is incompletely understood. In these studies, we treated wild-type (WT) and p47(phox)-deficient mice with LPS to investigate mechanisms by which NADPH oxidase regulates signaling through the NF-κB pathway. After intratracheal instil...

متن کامل

The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

Alpha-lipoic acid (ALA), occurring naturally in human food, is known to possess antioxidative and anti-inflammatory activities. Induction of heme oxygenase-1 (HO-1) has been reported to exhibit a therapeutic effect in several inflammatory diseases. The aim of study was to test the hypothesis that the protection of ALA against lipopolysaccharide-(LPS-) induced acute lung injury (ALI) is mediated...

متن کامل

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.

Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by enzymatic modification, eNOS may become uncoupled, producing superoxide in lieu of NO. This study was designed to investigate how eNOS-dependent superoxide production contributes to endothelial bar...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014